NUB1 Polyclonal Antibody

产品详情

产品名称

NUB1 Polyclonal Antibody

产品货号

YM-A19471

规格

50μL;100μL

种属反应

Human,Mouse,Monkey

实验应用

WB,IHC,IF,ELISA

分子量

70kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human NYREN18. AA range:566-615

特异性

NUB1 Polyclonal Antibody detects endogenous levels of NUB1 protein.

基因名称

NUB1

蛋白名称

NEDD8 ultimate buster 1

别名

NUB1;NYREN18;NEDD8 ultimate buster 1;Negative regulator of ubiquitin-like proteins 1;Renal carcinoma antigen NY-REN-18

基因ID-1

51667

SwissProt

Q9Y5A7

背景

This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici

细胞定位

Nucleus . Predominantly nuclear.