p107 Polyclonal Antibody

产品详情

产品名称

p107 Polyclonal Antibody

产品货号

YM-A19737

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications;

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human RBL1. AA range:335-384

特异性

p107 Polyclonal Antibody detects endogenous levels of p107 protein.

基因名称

RBL1

蛋白名称

Retinoblastoma-like protein 1

别名

RBL1;Retinoblastoma-like protein 1;107 kDa retinoblastoma-associated protein;p107;pRb1

基因ID-1

5933

SwissProt

P28749

背景

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms hav

细胞定位

Nucleus .