p140Cap Polyclonal Antibody

产品详情

产品名称

p140Cap Polyclonal Antibody

产品货号

YM-A19744

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

112kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human SNIP. AA range:811-860

特异性

p140Cap Polyclonal Antibody detects endogenous levels of p140Cap protein.

基因名称

SRCIN1

蛋白名称

SRC kinase signaling inhibitor 1

别名

SRCIN1;KIAA1684;P140;SRC kinase signaling inhibitor 1;SNAP-25-interacting protein;SNIP;p130Cas-associated protein;p140Cap

基因ID-1

80725

SwissProt

Q9C0H9

背景

function:Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells.,PTM:Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.,similarity:Belongs to the p140Cap family.,subcellular location:Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions.,subunit:Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.,

细胞定位

Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cell junction, synapse, postsynaptic density . Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. .