PARP-3 Polyclonal Antibody

产品详情

产品名称

PARP-3 Polyclonal Antibody

产品货号

YM-A19802

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IHC,IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PARP3. AA range:10-59

特异性

PARP-3 Polyclonal Antibody detects endogenous levels of PARP-3 protein.

基因名称

PARP3

蛋白名称

Poly [ADP-ribose] polymerase 3

别名

PARP3;ADPRT3;ADPRTL3;Poly [ADP-ribose] polymerase 3;PARP-3;hPARP-3;ADP-ribosyltransferase diphtheria toxin-like 3;ARTD3;IRT1;NAD;+;ADP-ribosyltransferase 3;ADPRT-3;Poly[ADP-ribose] synthase 3;pADPRT-3

基因ID-1

10039

SwissProt

Q9Y6F1

背景

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674). In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334). Preferentially localized to the daughter centriole (PubMed:10329013). .