MDR1 Polyclonal Antibody

产品详情

产品名称

MDR1 Polyclonal Antibody

产品货号

YM-A19882

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human P-glycoprotein 1. AA range:534-583

特异性

P-glycoprotein 1 Polyclonal Antibody detects endogenous levels of P-glycoprotein 1 protein.

基因名称

ABCB1

蛋白名称

Multidrug resistance protein 1

别名

p-pg;ABCB1;MDR1;PGY1;Multidrug resistance protein 1;ATP-binding cassette sub-family B member 1;P-glycoprotein 1;CD antigen CD243

基因ID-1

5243

SwissProt

P08183

背景

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008],

细胞定位

Cell membrane ; Multi-pass membrane protein . Apical cell membrane .