PIASx Polyclonal Antibody

产品详情

产品名称

PIASx Polyclonal Antibody

产品货号

YM-A19907

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Monkey

实验应用

WB,ELISA,IHC

分子量

68kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PIAS2. AA range:10-59

特异性

PIASx Polyclonal Antibody detects endogenous levels of PIASx protein.

基因名称

PIAS2

蛋白名称

E3 SUMO-protein ligase PIAS2

别名

PIAS2;PIASX;E3 SUMO-protein ligase PIAS2;Androgen receptor-interacting protein 3;ARIP3;DAB2-interacting protein;DIP;Msx-interacting zinc finger protein;Miz1;PIAS-NY protein;Protein inhibitor of activated STAT x;Protein inhibitor

基因ID-1

9063

SwissProt

O75928

背景

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011],

细胞定位

Nucleus speckle . Nucleus, PML body . Nucleus . Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). .