PP2A-B55-β Polyclonal Antibody

产品详情

产品名称

PP2A-B55-β Polyclonal Antibody

产品货号

YM-A19996

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC

分子量

51kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from PP2A-B55-β . at AA range: 90-170

特异性

PP2A-B55-β Polyclonal Antibody detects endogenous levels of PP2A-B55-β protein.

基因名称

PPP2R2B

蛋白名称

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

别名

PPP2R2B;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;PP2A subunit B isoform B55-beta;PP2A subunit B isoform PR55-beta;PP2A subunit B isoform R2-beta;PP2A subunit B isoform beta

基因ID-1

5521

SwissProt

Q00005

背景

protein phosphatase 2 regulatory subunit Bbeta(PPP2R2B) Homo sapiens The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isofor

细胞定位

[Isoform 1]: Cytoplasm . Cytoplasm, cytoskeleton . Membrane .; [Isoform 2]: Cytoplasm . Mitochondrion . Mitochondrion outer membrane . Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). .