PSD-95 Polyclonal Antibody

产品详情

产品名称

PSD-95 Polyclonal Antibody

产品货号

YM-A20043

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

95kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PSD-95. AA range:253-302

特异性

PSD-95 Polyclonal Antibody detects endogenous levels of PSD-95 protein.

基因名称

DLG4

蛋白名称

Disks large homolog 4

别名

DLG4;PSD95;Disks large homolog 4;Postsynaptic density protein 95;PSD-95;Synapse-associated protein 90;SAP-90;SAP90

基因ID-1

1742

SwissProt

P78352

背景

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

细胞定位

Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Cytoplasm . Cell projection, axon . Cell projection, dendritic spine . Cell projection, dendrite . Cell junction, synapse, presynapse . High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. .