PTTG1/2/3 Polyclonal Antibody

产品详情

产品名称

PTTG1/2/3 Polyclonal Antibody

产品货号

YM-A20063

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IHC,IF,ELISA

分子量

30kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human PTTG1. AA range:111-160

特异性

PTTG1/2/3 Polyclonal Antibody detects endogenous levels of PTTG1/2/3 protein.

基因名称

PTTG1

蛋白名称

Securin

别名

PTTG1;EAP1;PTTG;TUTR1;Securin;Esp1-associated protein;Pituitary tumor-transforming gene 1 protein;Tumor-transforming protein 1;hPTTG

基因ID-1

9232

SwissProt

O95997

背景

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been fo

细胞定位

Cytoplasm. Nucleus.