RFWD3 Polyclonal Antibody

产品详情

产品名称

RFWD3 Polyclonal Antibody

产品货号

YM-A20192

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

85kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human RFWD3. AA range:374-423

特异性

RFWD3 Polyclonal Antibody detects endogenous levels of RFWD3 protein.

基因名称

RFWD3

蛋白名称

E3 ubiquitin-protein ligase RFWD3

别名

RFWD3;RNF201;E3 ubiquitin-protein ligase RFWD3;RING finger and WD repeat domain-containing protein 3;RING finger protein 201

基因ID-1

55159

SwissProt

Q6PCD5

背景

PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 WD repeats.,

细胞定位

Nucleus . Nucleus, PML body . Cytoplasm . In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies (PubMed:21558276). In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair (PubMed:21504906, PubMed:28575657). This recruitment depends upon RPA2 (PubMed:21504906). .