RO60 Polyclonal Antibody

产品详情

产品名称

RO60 Polyclonal Antibody

产品货号

YM-A20284

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC

分子量

70kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human TROVE2. AA range:311-360

特异性

RO60 Polyclonal Antibody detects endogenous levels of RO60 protein.

基因名称

TROVE2

蛋白名称

60 kDa SS-A/Ro ribonucleoprotein

别名

TROVE2;RO60;SSA2;60 kDa SS-A/Ro ribonucleoprotein;60 kDa Ro protein;60 kDa ribonucleoprotein Ro;RoRNP;Ro 60 kDa autoantigen;Sjoegren syndrome antigen A2;Sjoegren syndrome type A antigen;SS-A;TROVE domain family member 2

基因ID-1

6738

SwissProt

P10155

背景

disease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign.,function:RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the Ro 60 kDa family.,similarity:Contains 1 TROVE domain.,subunit:Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.,

细胞定位

Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .