SGK1 Polyclonal Antibody

产品详情

产品名称

SGK1 Polyclonal Antibody

产品货号

YM-A20384

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IF,WB,IHC,ELISA

分子量

57kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;Not yet tested in other applications;

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human SGK. AA range:381-430

特异性

SGK1 Polyclonal Antibody detects endogenous levels of SGK1 protein.

基因名称

SGK1

蛋白名称

Serine/threonine-protein kinase Sgk1

别名

SGK1;SGK;Serine/threonine-protein kinase Sgk1;Serum/glucocorticoid-regulated kinase 1

基因ID-1

6446

SwissProt

O00141

背景

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009],

细胞定位

Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation.; [Isoform 2]: Cell membrane.