Siah-1/2 Polyclonal Antibody

产品详情

产品名称

Siah-1/2 Polyclonal Antibody

产品货号

YM-A20408

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

34kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human SIAH1. AA range:181-230

特异性

Siah-1/2 Polyclonal Antibody detects endogenous levels of Siah-1/2 protein.

基因名称

SIAH1/SIAH2

蛋白名称

E3 ubiquitin-protein ligase SIAH1/2

别名

SIAH1;HUMSIAH;E3 ubiquitin-protein ligase SIAH1;Seven in absentia homolog 1;Siah-1;Siah-1a;SIAH2;E3 ubiquitin-protein ligase SIAH2;Seven in absentia homolog 2;Siah-2;hSiah2

基因ID-1

6477;6478

SwissProt

Q8IUQ4;O43255

背景

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.