Stat2 Polyclonal Antibody

产品详情

产品名称

Stat2 Polyclonal Antibody

产品货号

YM-A20531

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IP,IHC,IF,ELISA

分子量

113kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human STAT2. AA range:656-705

特异性

Stat2 Polyclonal Antibody detects endogenous levels of Stat2 protein.

基因名称

STAT2

蛋白名称

Signal transducer and activator of transcription 2

别名

STAT2;Signal transducer and activator of transcription 2;p113

基因ID-1

6773

SwissProt

P52630

背景

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],

细胞定位

Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .