TIP60 Polyclonal Antibody

产品详情

产品名称

TIP60 Polyclonal Antibody

产品货号

YM-A20716

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IF,ELISA,IHC

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IF/ICC1:50-300;ELISA 1:2000-20000;IHC 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Tip60. AA range:56-105

特异性

TIP60 Polyclonal Antibody detects endogenous levels of TIP60 protein.

基因名称

KAT5

蛋白名称

Histone acetyltransferase KAT5

别名

KAT5;HTATIP;TIP60;Histone acetyltransferase KAT5;60 kDa Tat-interactive protein;Tip60;Histone acetyltransferase HTATIP;HIV-1 Tat interactive protein;Lysine acetyltransferase 5;cPLA;2;-interacting protein

基因ID-1

10524

SwissProt

Q92993

背景

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus . Chromosome . Cytoplasm . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Nucleus, nucleolus . Cytoplasm, perinuclear region . Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386). Transiently localizes to kinetochores in early mitosis (PubMed:26829474). Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293). Localizes in the cytoplasm and nucleus of round spermatids (By similarity). .