TIRAP Polyclonal Antibody

产品详情

产品名称

TIRAP Polyclonal Antibody

产品货号

YM-A20717

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IHC,IF,WB,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human TIRAP. AA range:52-101

特异性

TIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein.

基因名称

TIRAP

蛋白名称

Toll/interleukin-1 receptor domain-containing adapter protein

别名

TIRAP;MAL;Toll/interleukin-1 receptor domain-containing adapter protein;TIR domain-containing adapter protein;Adaptor protein Wyatt;MyD88 adapter-like protein

基因ID-1

114609

SwissProt

P58753

背景

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Cell membrane . Membrane . Colocalizes with DAB2IP at the plasma membrane.