TNF-R1 Polyclonal Antibody

产品详情

产品名称

TNF-R1 Polyclonal Antibody

产品货号

YM-A20737

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC,IF,WB,ELISA

分子量

50kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human TNF Receptor I. AA range:381-430

特异性

TNF-R1 Polyclonal Antibody detects endogenous levels of TNF-R1 protein.

基因名称

TNFRSF1A

蛋白名称

Tumor necrosis factor receptor superfamily member 1A

别名

TNFRSF1A;TNFAR;TNFR1;Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor 1;TNF-R1;Tumor necrosis factor receptor type I;TNF-RI;TNFR-I;p55;p60;CD antigen CD120a

基因ID-1

7132

SwissProt

P19438

背景

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by Re

细胞定位

Cell membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Secreted . A secreted form is produced through proteolytic processing.; [Isoform 4]: Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.