VEGF-A Polyclonal Antibody

产品详情

产品名称

VEGF-A Polyclonal Antibody

产品货号

YM-A20913

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Pig,Rabbit

实验应用

WB,IF,IHC,ELISA

分子量

21kD(monomer),42kD(dimer)

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000.IF 1:50-200;IHC 1:100-1:300;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human VEGF-A. AA range:110-159

特异性

VEGF-A Polyclonal Antibody detects endogenous levels of VEGF-A protein.

基因名称

VEGFA

蛋白名称

Vascular endothelial growth factor A

别名

VEGFA;VEGF;Vascular endothelial growth factor A;VEGF-A;Vascular permeability factor;VPF

基因ID-1

7422

SwissProt

P15692

背景

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation fro

细胞定位

Secreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.