ZP4 Polyclonal Antibody

产品详情

产品名称

ZP4 Polyclonal Antibody

产品货号

YM-A21028

规格

50μL;100μL

种属反应

Human,Rat

实验应用

WB,ELISA

分子量

65kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human ZP4. AA range:231-280

特异性

ZP4 Polyclonal Antibody detects endogenous levels of ZP4 protein.

基因名称

ZP4

蛋白名称

Zona pellucida sperm-binding protein 4

别名

ZP4;ZPB;Zona pellucida sperm-binding protein 4;Zona pellucida glycoprotein 4;Zp-4;Zona pellucida protein B

基因ID-1

57829

SwissProt

Q12836

背景

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been

细胞定位

[Processed zona pellucida sperm-binding protein 4]: Zona pellucida .; Cell membrane ; Single-pass type I membrane protein .