Myosin VI Polyclonal Antibody

产品详情

产品名称

Myosin VI Polyclonal Antibody

产品货号

YM-A21093

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

149kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC: 1:100-300;ELISA 1:5000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from Myosin VI . at AA range: 40-120

特异性

Myosin VI Polyclonal Antibody detects endogenous levels of Myosin VI protein.

基因名称

MYO6

蛋白名称

Unconventional myosin-VI

别名

MYO6;KIAA0389;Unconventional myosin-VI;Unconventional myosin-6

基因ID-1

4646

SwissProt

Q9UM54

背景

myosin VI(MYO6) Homo sapiens This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],

细胞定位

Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Golgi apparatus . Nucleus . Cytoplasm, perinuclear region . Membrane, clathrin-coated pit . Cytoplasmic vesicle, clathrin-coated vesicle . Cell projection, filopodium . Cell projection, ruffle membrane . Cell projection, microvillus . Cytoplasm, cytosol . Also present in endocyctic vesicles (PubMed:16507995). Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995). Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149). Colocalizes with DAB2 in clathrin-coated pits/vesicles (PubMed:11967127). Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (By similarity). .; [Isoform 3]: Cytoplasmic vesicle, clathrin-coated vesicle membrane .; [Isoform 4]: Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell projection, ruffle membrane .