NPRL2 Polyclonal Antibody

产品详情

产品名称

NPRL2 Polyclonal Antibody

产品货号

YM-A21107

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

43kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from the C-terminal region of human NPRL2.

特异性

NPRL2 Polyclonal Antibody detects endogenous levels of NPRL2 protein.

基因名称

NPRL2

蛋白名称

Nitrogen permease regulator 2-like protein

别名

NPRL2;TUSC4;Nitrogen permease regulator 2-like protein;NPR2-like protein;Gene 21 protein;G21 protein;Tumor suppressor candidate 4

基因ID-1

10641

SwissProt

Q8WTW4

背景

function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.,similarity:Belongs to the NPR2 family.,subunit:Interacts with PDPK1.,tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.,

细胞定位

Lysosome membrane . Localization to lysosomes is amino acid-independent. .