CYP2A6/7/13 Polyclonal Antibody

产品详情

产品名称

CYP2A6/7/13 Polyclonal Antibody

产品货号

YM-A21113

规格

50μL;100μL

种属反应

Human

实验应用

WB,ELISA

分子量

56kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from the Internal region of human CYP2A6/7/13.

特异性

CYP2A6/7/13 Polyclonal Antibody detects endogenous levels of CYP2A6/7/13 protein.

基因名称

CYP2A6/CYP2A7/CYP2A13

蛋白名称

Cytochrome P450 2A6/Cytochrome P450 2A7/Cytochrome P450 2A13

别名

CYP2A6;CYP2A3;Cytochrome P450 2A6;1,4-cineole 2-exo-monooxygenase;CYPIIA6;Coumarin 7-hydroxylase;Cytochrome P450 IIA3;Cytochrome P450;I;CYP2A7;Cytochrome P450 2A7;CYPIIA7;Cytochrome P450 IIA4;CYP2A13;Cytochrome P450 2A13;CYPIIA13

基因ID-1

1553

SwissProt

P11509;P20853;Q16696

背景

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008],

细胞定位

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.