ASIC3 Polyclonal Antibody

产品详情

产品名称

ASIC3 Polyclonal Antibody

产品货号

YM-A21203

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,ELISA

分子量

58kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human ASIC3. AA range:191-240

特异性

ASIC3 Polyclonal Antibody detects endogenous levels of ASIC3 protein.

基因名称

ASIC3

蛋白名称

Acid-sensing ion channel 3

别名

ASIC3;ACCN3;SLNAC1;TNAC1;Acid-sensing ion channel 3;ASIC3;hASIC3;Amiloride-sensitive cation channel 3;Neuronal amiloride-sensitive cation channel 3;Testis sodium channel 1;hTNaC1

基因ID-1

9311

SwissProt

Q9UHC3

背景

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012],

细胞定位

Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). .