p57 Polyclonal Antibody

产品详情

产品名称

p57 Polyclonal Antibody

产品货号

YM-A21318

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IF,ELISA

分子量

32kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human p57Kip2 around the non-acetylation site of Lys278. AA range:241-290

特异性

p57 Polyclonal Antibody detects endogenous levels of p57 protein.

基因名称

CDKN1C

蛋白名称

Cyclin-dependent kinase inhibitor 1C

别名

CDKN1C;KIP2;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent kinase inhibitor p57;p57Kip2

基因ID-1

1028

SwissProt

P49918

背景

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],

细胞定位

Nucleus .