CD42b Polyclonal Antibody

产品详情

产品名称

CD42b Polyclonal Antibody

产品货号

YM-A21364

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

69kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human GP1BA. AA range:271-320

特异性

CD42b Polyclonal Antibody detects endogenous levels of CD42b protein.

基因名称

GP1BA

蛋白名称

Platelet glycoprotein Ib alpha chain

别名

GP1BA;Platelet glycoprotein Ib alpha chain;GP-Ib alpha;GPIb-alpha;GPIbA;Glycoprotein Ibalpha;Antigen CD42b-alpha;CD42b

基因ID-1

2811

SwissProt

P07359

背景

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is

细胞定位

Membrane; Single-pass type I membrane protein.