PPP1R15B Polyclonal Antibody

产品详情

产品名称

PPP1R15B Polyclonal Antibody

产品货号

YM-A21503

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

78kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human PPP1R15B. AA range:411-460

特异性

PPP1R15B Polyclonal Antibody detects endogenous levels of PPP1R15B protein.

基因名称

PPP1R15B

蛋白名称

Protein phosphatase 1 regulatory subunit 15B

别名

PPP1R15B;Protein phosphatase 1 regulatory subunit 15B

基因ID-1

84919

SwissProt

Q5SWA1

背景

This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with mi

细胞定位

protein phosphatase type 1 complex,