PSGL-1 Polyclonal Antibody

产品详情

产品名称

PSGL-1 Polyclonal Antibody

产品货号

YM-A21504

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

45kD,110kD(glycosylated)

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELPLG. AA range:1-50

特异性

PSGL-1 Polyclonal Antibody detects endogenous levels of PSGL-1 protein.

基因名称

SELPLG

蛋白名称

P-selectin glycoprotein ligand 1

别名

SELPLG;P-selectin glycoprotein ligand 1;PSGL-1;Selectin P ligand;CD162

基因ID-1

6404

SwissProt

Q14242

背景

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011],

细胞定位

Membrane; Single-pass type I membrane protein.