CD101 Polyclonal Antibody

产品详情

产品名称

CD101 Polyclonal Antibody

产品货号

YM-A21528

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

130kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human CD101. AA range:731-780

特异性

CD101 Polyclonal Antibody detects endogenous levels of CD101 protein.

基因名称

CD101

蛋白名称

Immunoglobulin superfamily member 2

别名

CD101;EWI101;IGSF2;V7;Immunoglobulin superfamily member 2;IgSF2;Cell surface glycoprotein V7;Glu-Trp-Ile EWI motif-containing protein 101;EWI-101;CD101

基因ID-1

9398

SwissProt

Q93033

背景

function:Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.,PTM:N-glycosylated.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.,

细胞定位

Membrane ; Single-pass type I membrane protein .