IL-12Rβ1 Polyclonal Antibody

产品详情

产品名称

IL-12Rβ1 Polyclonal Antibody

产品货号

YM-A21539

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

73kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human IL12RB1. AA range:211-260

特异性

IL-12Rβ1 Polyclonal Antibody detects endogenous levels of IL-12Rβ1 protein.

基因名称

IL12RB1

蛋白名称

Interleukin-12 receptor subunit beta-1

别名

IL12RB1;IL12R;IL12RB;Interleukin-12 receptor subunit beta-1;IL-12 receptor subunit beta-1;IL-12R subunit beta-1;IL-12R-beta-1;IL-12RB1;IL-12 receptor beta component;CD212

基因ID-1

3594

SwissProt

P42701

背景

interleukin 12 receptor subunit beta 1(IL12RB1) Homo sapiens The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

细胞定位

Membrane; Single-pass type I membrane protein.