SIRP-α1/β1 Polyclonal Antibody

产品详情

产品名称

SIRP-α1/β1 Polyclonal Antibody

产品货号

YM-A21547

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,IHC,IF,ELISA

分子量

55kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human SIRPA/SIRPB1. AA range:281-330

特异性

SIRP-α1/β1 Polyclonal Antibody detects endogenous levels of SIRP-α1/β1 protein.

基因名称

SIRPA/SIRPB1

蛋白名称

Tyrosine-protein phosphatase non-receptor type substrate 1/Signal-regulatory protein beta-1 isoform 3

别名

SIRPA;BIT;MFR;MYD1;PTPNS1;SHPS1;SIRP;Tyrosine-protein phosphatase non-receptor type substrate 1;SHP substrate 1;SHPS-1;Brain Ig-like molecule with tyrosine-based activation motifs;Bit;CD172 antigen-like family member A;Inhibitory receptor SHPS-1;Macrophage fusion receptor;MyD-1 antigen;Signal-regulatory protein alpha-1;Sirp-alpha-1;Signal-regulatory protein alpha-2;Sirp-alpha-2;Signal-regulatory protein alpha-3;Sirp-alpha-3;p84;CD172a;SIRPB1;Signal-regulatory protein beta-1 isoform 3;SIRP-beta-1 isoform 3

基因ID-1

140885;10326;100653194

SwissProt

P78324;Q5TFQ8

背景

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternati

细胞定位

Membrane; Single-pass type I membrane protein.