Neuregulin-3 Polyclonal Antibody

产品详情

产品名称

Neuregulin-3 Polyclonal Antibody

产品货号

YM-A21569

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,ELISA

分子量

80kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from the Internal region of human NRG3. AA range:311-360

特异性

Neuregulin-3 Polyclonal Antibody detects endogenous levels of Neuregulin-3 protein.

基因名称

NRG3

蛋白名称

Pro-neuregulin-3 membrane-bound isoform

别名

NRG3;Pro-neuregulin-3, membrane-bound isoform;Pro-NRG3

基因ID-1

10718

SwissProt

P56975

背景

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri

细胞定位

[Pro-neuregulin-3, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-3]: Secreted .; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Isoform 3 is also proteolytically released as a soluble form.