COL25A1 Polyclonal Antibody

产品详情

产品名称

COL25A1 Polyclonal Antibody

产品货号

YM-A21707

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

64kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;ELISA 1:10000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthetic peptide from human protein at AA range: 101-150

特异性

The antibody detects endogenous COL25A1 protein

基因名称

COL25A1

蛋白名称

collagen, type XXV, alpha 1

别名

COL25A1

基因ID-1

84570

SwissProt

Q9BXS0

背景

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

细胞定位

Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.