CD299 Polyclonal Antibody

产品详情

产品名称

CD299 Polyclonal Antibody

产品货号

YM-A21760

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

60kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:500-200;ELISA 1:10000-20000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthetic peptide from human protein at AA range: 271-320

特异性

The antibody detects endogenous CD299

基因名称

CLEC4M CD209L CD209L1 CD299

蛋白名称

C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)

别名

C-type lectin domain family 4 member M;CD209 antigen-like protein 1;DC-SIGN-related protein;DC-SIGNR;Dendritic cell-specific ICAM-3-grabbing non-integrin 2;DC-SIGN2;Liver/lymph node-specific ICAM-3-grabbing non-integrin;L-SIGN;CD antigen CD299;

基因ID-1

10332

SwissProt

Q9H2X3

背景

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations

细胞定位

[Isoform 1]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 5]: Secreted .; [Isoform 6]: Secreted .; [Isoform 7]: Secreted .; [Isoform 10]: Secreted .