PCP Polyclonal Antibody

产品详情

产品名称

PCP Polyclonal Antibody

产品货号

YM-A21993

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

IHC,IF,WB

分子量

100kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

IHC 1:50-200;WB 1:500-2000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human PCP

特异性

This antibody detects endogenous levels of human PCP

基因名称

PRCP PCP

蛋白名称

PCP

别名

Lysosomal Pro-X carboxypeptidase;Angiotensinase C;Lysosomal carboxypeptidase C;Proline carboxypeptidase;Prolylcarboxypeptidase;PRCP;

基因ID-1

5547

SwissProt

P42785

背景

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [pr

细胞定位

Lysosome.