DEN1A rabbit pAb

产品详情

产品名称

DEN1A rabbit pAb

产品货号

YM-A22883

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB

分子量

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human DEN1A AA range: 14-64

特异性

This antibody detects endogenous levels of DEN1A at Human/Mouse

基因名称

DENND1A FAM31A KIAA1608

蛋白名称

DEN1A

别名

基因ID-1

57706

SwissProt

Q8TEH3

背景

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],

细胞定位

Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane . Associates to membranes via lipid-binding activity. .