HER2 (Phospho Tyr1221/1222) Rabbit mAb

产品详情

产品名称

HER2 (Phospho Tyr1221/1222) Rabbit mAb

产品货号

YM-A25259

规格

50μL;100μL

种属反应

Human

实验应用

WB,IF,IP,ELISA

分子量

185kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

Phospho Tyr1221/1222

推荐稀释比

WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

克隆号

PT0740R

免疫原

特异性

The antibody detects endogenous HER2(Phospho AE13) protein.

基因名称

ERBB2 HER2 MLN19 NEU NGL

蛋白名称

Her-2

别名

Receptor tyrosine-protein kinase erbB-2;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD antigen CD340;

基因ID-1

2064

SwissProt

P04626

背景

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

细胞定位

Membrane