TBC1D4 Rabbit mAb

产品详情

产品名称

TBC1D4 Rabbit mAb

产品货号

YM-A25464

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IF,IP,ELISA

分子量

160kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

推荐稀释比

WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

克隆号

PT0652R

免疫原

特异性

Endogenous

基因名称

TBC1D4

蛋白名称

TBC1 domain family member 4

别名

TBC1D4;AS160;KIAA0603;TBC1 domain family member 4;Akt substrate of 160 kDa;AS160

基因ID-1

9882

SwissProt

O60343

背景

This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph

细胞定位

Cytoplasm