STAT6 Rabbit mAb

产品详情

产品名称

STAT6 Rabbit mAb

产品货号

YM-A25468

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

WB,IHC,IF,IP,ELISA

分子量

110kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

推荐稀释比

IHC 1:500-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

克隆号

PT0623R

免疫原

特异性

Endogenous

基因名称

STAT6

蛋白名称

Signal transducer and activator of transcription 6

别名

STAT6;Signal transducer and activator of transcription 6;IL-4 Stat

基因ID-1

6778

SwissProt

P42226

背景

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

细胞定位

Nucleus