LATS1 Rabbit mAb

产品详情

产品名称

LATS1 Rabbit mAb

产品货号

YM-A25479

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

WB,IF,IP,ELISA

分子量

140kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

推荐稀释比

WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

克隆号

PT0609R

免疫原

特异性

Endogenous

基因名称

LATS1 WARTS

蛋白名称

Serine/threonine-protein kinase LATS1 (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)

别名

Serine/threonine-protein kinase LATS1;Large tumor suppressor homolog 1;WARTS protein kinase;h-warts;

基因ID-1

9113

SwissProt

O95835

背景

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen

细胞定位

Cytoplasm