Bim Rabbit mAb

产品详情

产品名称

Bim Rabbit mAb

产品货号

YM-A25495

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

WB,IF,IP,ELISA

分子量

22kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

推荐稀释比

WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

克隆号

PT0603R

免疫原

特异性

Endogenous

基因名称

BCL2L11

蛋白名称

Bcl-2-like protein 11

别名

BCL2L11;BIM;Bcl-2-like protein 11;Bcl2-L-11;Bcl2-interacting mediator of cell death

基因ID-1

10018

SwissProt

O43521

背景

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013],

细胞定位

Endomembrane