PUMA Rabbit mAb

产品详情

产品名称

PUMA Rabbit mAb

产品货号

YM-A25498

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

WB,IHC,IF,IP,ELISA

分子量

21kD

宿主

Rabbit

同种型

IgG,Kappa

修饰

推荐稀释比

IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

克隆号

PT0607R

免疫原

特异性

Endogenous

基因名称

BBC3

蛋白名称

Bcl-2-binding component 3

别名

BBC3;PUMA;Bcl-2-binding component 3;JFY-1;p53 up-regulated modulator of apoptosis

基因ID-1

27113

SwissProt

Q9BXH1

背景

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],

细胞定位

Mitochondrion